Tuesday, April 20, 2021
Matchday 1 · Matchday 16Friday, April 23, 2021
Matchday 23Saturday, April 24, 2021
Matchday 23Wednesday, April 28, 2021
Matchday 10Thursday, April 29, 2021
Matchday 24Friday, April 30, 2021
Matchday 24Saturday, May 1, 2021
Matchday 24Tuesday, May 4, 2021
Matchday 25Wednesday, May 5, 2021
Matchday 25Saturday, May 8, 2021
Matchday 26| # | Team | P | GD | Pts | Form |
|---|---|---|---|---|---|
| 1 |  Dynamo Kyiv U21 | 26 | +76 | 69 | |
| 2 |  Shakhtar Donetsk U21 | 26 | +51 | 62 | |
| 3 |  Rukh Vynnyky U21 | 26 | +30 | 52 | |
| 4 |  Oleksandria U21 | 26 | +27 | 50 | |
| 5 |  Vorskla U21 | 26 | +17 | 43 | |
| 6 |  Dnipro-1 U21 | 26 | +11 | 42 | |
| 7 |  Kolos Kovalivka U21 | 26 | +15 | 40 | |
| 8 |  Mariupol' U21 | 26 | +5 | 39 | |
| 9 |  Zorya Luhansk U21 | 26 | -3 | 34 | |
| 10 |  Lviv U21 | 26 | -4 | 27 | |
| 11 |  Minai U21 | 26 | -39 | 19 | |
| 12 |  Olimpik Donetsk U21 | 26 | -56 | 16 | |
| 13 |  Desna U21 | 26 | -53 | 14 | |
| 14 |  Inhulets' U21 | 26 | -77 | 10 |